Involvement of interleukin-17 during lymphocytic bronchiolitis in lung transplant patients

SE Verleden, R Vos, E Vandermeulen… - The Journal of Heart and …, 2013 - Elsevier
BACKGROUND: Interleukin-17 (IL-17) is involved in autoimmune and chronic pulmonary
diseases and linked with neutrophilic inflammation. Azithromycin reduces and prevents
broncholaveolar lavage (BAL) neutrophilia after lung transplantation (LTx). In this
investigation we assessed the involvement of IL-17 in different post-transplant complications
in human LTx biopsies. METHODS: Immunohistochemical staining against IL-17A was
performed on biopsies of LTx patients with either chronic rejection, acute A-grade rejection …