[HTML][HTML] New insights into functions of the sphingosine-1-phosphate transporter SPNS2
S Spiegel, MA Maczis, M Maceyka, S Milstien - Journal of lipid research, 2019 - ASBMB
Sphingosine-1-phosphate (S1P) is a potent bioactive signaling molecule that regulates
many physiological processes important for development, epithelial and endothelial barrier
integrity, and the immune system, as well as for pathologies, such as autoimmune diseases,
cancer, and metastasis. Most of the well-known actions of S1P are mediated by five specific
G protein-coupled receptors located on the plasma membrane. Because S1P is synthesized
intracellularly by two sphingosine kinase isoenzymes, we have proposed the paradigm of …
many physiological processes important for development, epithelial and endothelial barrier
integrity, and the immune system, as well as for pathologies, such as autoimmune diseases,
cancer, and metastasis. Most of the well-known actions of S1P are mediated by five specific
G protein-coupled receptors located on the plasma membrane. Because S1P is synthesized
intracellularly by two sphingosine kinase isoenzymes, we have proposed the paradigm of …
